Therini Bio, Inc., a Sacramento, CA-based clinical-stage biotech company developing fibrin-targeting immunotherapies for neurodegenerative diseases driven by vascular dysfunction raised $39m in Series A extension financing.
The extension financing included new investors, Angelini Ventures and Apollo Health Ventures, in addition to existing investors SV Health Investors’ Biotech Fund and Dementia Discovery Fund, MRL Ventures Fund, Sanofi Ventures, Eli Lilly and Company, Dolby Family Ventures and Foundation for a Better World. This financing increased Therini Bio’s Series A total to $75M.
The company will use the proceeds to fund Phase 1b trials evaluating its lead candidate, THN391, for the treatment of Alzheimer’s Disease (AD) and Diabetic Macular Edema (DME), as well as support development of a fibrin/VEGF bispecific.
Led by Tara Nickerson, Ph.D., Chief Executive Officer, Therini Bio seeks to target the underlying causes of neurodegeneration. Factors such as aging, genetics and prevalent diseases, such as hypertension and diabetes, lead to vascular dysfunction and the accumulation of toxic fibrin deposits outside of blood vessels. These deposits induce chronic neuroinflammation, resulting in neuronal damage and severe neurogenerative diseases. Therini Bio has developed a novel approach aimed at treating these devastating diseases by specifically targeting the inflammatory epitope on fibrin to halt the destructive effects of neuroinflammation.
THN391, a potential first-in-class, high-affinity humanized monoclonal antibody designed to selectively block fibrin-mediated neuroinflammation without affecting coagulation pathways, demonstrated activity in preventing vascular and neuronal degeneration in preclinical studies of AD and retinal diseases. In a recent Phase 1a trial, THN391 was well-tolerated in healthy volunteers, showed no adverse hematological effects or impact on coagulation and fibrinolysis, lacked an anti-drug antibody response and had dose-proportional pharmacokinetics with a half-life supporting monthly dosing. Supported by the current data and financing, the team at Therini Bio is preparing to begin dosing patients in Phase 1b trials evaluating THN391 in AD and DME.
FinSMEs
15/05/2025