HomeUSARejuvenate Bio Receives $4M in Funding

Rejuvenate Bio Receives $4M in Funding

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Rejuvenate Bio

Rejuvenate Bio, a San Diego, CA-based biotechnology company dedicated to developing novel gene therapies for chronic age-related diseases, received $4M in grant from California Institute for Regenerative Medicine (CIRM).

The company intends to use the funds to complete its IND-enabling activities for the development of RJB-0402 for the treatment of desmoplakin gene variant arrhythmogenic cardiomyopathy (DSP ACM).

Led by Dan Oliver, CEO, and Chief Scientific Officer Noah Davidsohn, Ph.D., Rejuvenate Bio is a biotechnology company dedicated to developing novel gene therapies for chronic age-related diseases. Rejuvenate Bio has built a gene therapy pipeline with huge potential in chronic disease by utilizing clinically validated gene targets and a delivery approach that ensures well tolerated, durable expression. Founded on scientific research developed at the Wyss Institute at Harvard Medical School, Rejuvenate Bio has developed therapies to treat chronic age-related disease in both humans and animals.

RJB-0402 is a novel systemically administered investigational AAV8 gene therapy that drives liver specific expression of FGF21 protein, targeting multiple key pathological drivers of DSP ACM. Since the DSP gene is too large for gene replacement therapy, novel strategies are needed to treat DSP ACM. FGF21 has known salutary effects on cardiac dysfunction as well as ventricular arrhythmias, adipogenesis, inflammation, and fibrosis, all of which are DSP ACM hallmarks. Furthermore, clinical efficacy of RJB-0402 in DSP ACM may form the basis for the treatment in other forms of ACM.

FinSMEs

02/07/2024